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Telomeres and telomerase in radio-sensitivity and gene amplification
Telomeres and telomerase play key roles in the maintenance of genome stability. Chiara Mondello, in collaboration with Elena Giulotto, has shown that in telomerase expressing cells, very short telomeres do not increase cellular and chromosomal radiosensitivity, as they do in t...
Programme: FP5-EAECTP C
Record Number: 44380
Last updated on: 2007-08-22
Telomeres and radiosensitivity of individuals
ID: FIGH-CT-2002-00217
Start date: 2003-01-01, End date: 2005-12-31
Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that ...
Programme: FP5-EAECTP C
Record Number: 67972
Last updated on: 2003-04-01
Double strand break repair functions and gene amplification
It is known that DNA-PKcs is a key protein for the repair of DSBs through the NHEJ pathway and that DSBs can initiate gene amplification. The results obtained by Elena Giulotto and Chiara Mondello indicate that in human cells an impairment in DNA-PKcs function increases the pr...
Programme: FP5-EAECTP C
Record Number: 44379
Last updated on: 2007-08-22
Integral large scale experiments on hydrogen combustion for severe accident code validation
ID: FIKS-CT-1999-00004
Start date: 2000-02-01, End date: 2003-01-31
Hydrogen posses a major threat to containment integrity in the case of a severe accident in a nuclear power plant. Reliable analysis of severe accident situations and optimisation of mitigation designs are essential for enhancing safety and avoiding unnecessary conservatism...
Programme: FP5-EAECTP C
Record Number: 52742
Last updated on: 2002-09-10
Biokinetics and dosimetry of internal contamination
ID: FIGD-CT-2000-00053
Start date: 2001-01-01, End date: 2004-06-30
The assessment of doses and risks from radionuclide exposures is critically dependent on the development of reliable biokinetic and dosimetric models to represent the behaviour of radionuclides in the body and energy deposition in sensitive cells. This proposal from eleven....
Programme: FP5-EAECTP C
Record Number: 54207
Last updated on: 2003-04-01
European Validation of the Integral Code ASTEC
ID: FIKS-CT-1999-00010
Start date: 2000-02-01, End date: 2003-07-31
The ultimate intention beyond this shared cost action is to provide end-users like utilities, vendors and licensing authorities with a well-validated European Integral Code for the simulation of severe accident sequences in NPPs. The main objective of this proposal is to...
Programme: FP5-EAECTP C
Record Number: 51301
Last updated on: 2003-09-12
Selective extraction of minor actinides from high activity liquid waste by organized matrices
ID: FIKW-CT-2000-00088
Start date: 2000-10-01, End date: 2004-01-31
High activity waste, which contain long life minor actinides, are currently vitrified for their storage in geological formation. In order to decrease the potential toxicity of this wastes the selective removing of these minor actinidesis studied in order to destroy them by...
Programme: FP5-EAECTP C
Record Number: 52389
Last updated on: 2004-09-08
In-flight measurements of route doses by the ANPA stack
The data obtained with the ANPA stack on hundreds of repeated return long-haul flights on the routes Milan-Los Angeles, Milan-Tokyo and Rome Rio-de Janeiro have been used to study the reproducibility of the route dose at different phases of the solar cycle. These data have p...
Programme: FP5-EAECTP C
Record Number: 36072
Last updated on: 2005-04-12
Interlaboratory radiochemical analysis comparison on a primary waste flux
ID: FIKW-CT-2000-00006
Start date: 2000-09-01, End date: 2002-08-31
The aim of the project is to perform an interlaboratory radiochemical analysis campaign on the destructive measurement of radiotoxic and long-lived radionuclides in a primary waste flux from NPP's. An accurate knowledge of the inventory of these radionuclides is a critical par...
Programme: FP5-EAECTP C
Record Number: 52865
Last updated on: 2017-12-22
Processes regulating remobilisation, bioavailability and translocation of radionuclides in marine sediments
ID: FIGE-CT-2000-00085
Start date: 2000-11-01, End date: 2003-10-31
The aim of the project is to study remobilisation of radiologically, important radionuclides from sediments of different characteristics in different European environments. Transboundary exposure has to be taken into account into the modelling and assessment of committed doses...
Programme: FP5-EAECTP C
Record Number: 52925
Last updated on: 2003-10-02
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