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Final Report Summary - TRANSDEATH (Programmed cell death across the eukaryotic kingdom)
Programmed cell death (PCD) is normally invoked during development and immunity, but inappropriate PCD is associated with pathologies including cancer and degenerative diseases. Genes controlling one type of PCD (apoptosis) were first identified in the worm model C. elegans. B...
Record Number: 51807
Last updated on: 2011-04-14
Final Report Summary - GENOMES_TO_VACCINES (Translating genome and proteome information into immune recognition)
Genome information is accumulating rapidly and it encompasses a wide range of species, including humans and many pathogens, among others. It is now possible to completely sequence microbial genomes within a period ranging from days to months, and genomics can therefore be used...
Record Number: 51616
Last updated on: 2011-04-14
Final Report Summary - MSCNET (Myeloma Stem Cell Network - A translational programme identifying and targeting the early myeloma cell hierarchy)
Multiple myeloma (MM) is a neoplasia defined by the accumulation of malignant plasma cells in the bone marrow. Many recent therapeutic advances have extended survival, but are not curative and new approaches are being sought that can underpin disease resolution. Understanding ...
Record Number: 49698
Last updated on: 2011-04-14
Development of New Drugs for the Treatment of Malaria
ID: 18834
Start date: 2005-12-01, End date: 2011-05-31
Leading groups of malaria researchers will integrate their expertise in malaria biology and drug development to exploit new scientific and political opportunities to secure the development of a portfolio of viable novel AntiMalarial drugs. New chemical entities will be commerc...
Record Number: 78405
Last updated on: 2011-12-20
Functional Genomic diagnostic tools for coronary artery disease
ID: 37683
Start date: 2007-01-01, End date: 2010-06-30
The theme of this proposal is to develop methodologies that integrate functional genomic tools and genetic strategies to address major unresolved questions concerning the molecular basis of common diseases using coronary artery disease (CAD) as an example. Progress in function...
Record Number: 85024
Last updated on: 2010-10-20
ENFIN - an experimental network for functional integration
ID: 518254
Start date: 2005-11-15, End date: 2011-05-14
We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but u...
Record Number: 75903
Last updated on: 2013-03-26
Innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation
ID: 518167
Start date: 2005-11-01, End date: 2010-10-31
The general objective of INNOCHEM is to develop innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation. The project is based on the scientific excellence of the applicants, which have made major recognized contributions to the field since t...
Record Number: 85793
Last updated on: 2011-03-02
RNA Interference Technology as Human Therapeutic Tool
ID: 5276
Start date: 2005-01-01, End date: 2009-06-30
The RIGHT project aims at exploiting the vast potential of RNA interference (RNAi) for human therapy, based on an advanced understanding of the underlying mechanisms. Rational and selective approaches will be taken to generate efficient RNAi reagents, and strategies will be de...
Record Number: 74045
Last updated on: 2013-03-26
Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome
ID: 5272
Start date: 2005-01-01, End date: 2009-12-31
The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these condition...
Record Number: 74044
Last updated on: 2010-10-20
Glutamate receptor proteins as novel neuroprotective targets
ID: 5320
Start date: 2005-08-01, End date: 2008-07-31
Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington's disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens for a new strategical ap...
Record Number: 81219
Last updated on: 2013-03-26
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List retrieved on: 2018-03-20
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