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Final Report Summary - NCL-MODELS (Dissecting neuronal degeneration: Neuronal ceroid lipofuscinoses from genes to function)
The Neuronal ceroid lipofuscinoses (NCLs) are collectively the most common inherited progressive encephalopathy of childhood. Each form of NCL is characterised by the progressive death of CNS neurons and these rare diseases provide an excellent model to define the molecular ev...
Record Number: 51611
Last updated on: 2011-04-14
Integrated genomics, clinical research and care in hypertension
ID: 37093
Start date: 2006-11-01, End date: 2011-01-31
The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics,...
Record Number: 84934
Last updated on: 2013-03-26
Identification of genetic roots of coronary artery disease by combining stepwise genome wide association studies with transcriptomic and functional genomic investigation of relevant genetic variants
ID: 37593
Start date: 2006-10-01, End date: 2011-03-31
The heritability of coronary artery disease (CAD) and myocardial infarction (MI) has been unequivocally demonstrated. However, traditional technology, for example based on investigation of candidate genes, or linkage analysis, has failed to elucidate the genetic roots of the N...
Record Number: 85010
Last updated on: 2013-03-26
Epigenetic treatment of neoplastic disease
ID: 518417
Start date: 2005-11-01, End date: 2011-04-30
Chromatin is epigenetically modified to regulate gene expression. Upstream signals induce complex patterns of enzyme-catalyzed modifications of DNA and histones, key protein components of chromatin. These epigenetic modifications create docking sites for other regulators and f...
Record Number: 78780
Last updated on: 2011-05-30
ENFIN - an experimental network for functional integration
ID: 518254
Start date: 2005-11-15, End date: 2011-05-14
We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but u...
Record Number: 75903
Last updated on: 2013-03-26
Clinical Neuroproteomics of Neurodegenerative Diseases
ID: 37950
Start date: 2007-04-01, End date: 2010-09-30
Alzheimer's dementia (AD) is one of the most common brain diseases in the elderly. Dementias pose a major health problem in European countries, with currently 5.7 million affected dementia patients in the EU25. Currently no curative therapies are available for these dementias,...
Record Number: 100542
Last updated on: 2011-09-26
RNA Interference Technology as Human Therapeutic Tool
ID: 5276
Start date: 2005-01-01, End date: 2009-06-30
The RIGHT project aims at exploiting the vast potential of RNA interference (RNAi) for human therapy, based on an advanced understanding of the underlying mechanisms. Rational and selective approaches will be taken to generate efficient RNAi reagents, and strategies will be de...
Record Number: 74045
Last updated on: 2013-03-26
Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome
ID: 5272
Start date: 2005-01-01, End date: 2009-12-31
The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these condition...
Record Number: 74044
Last updated on: 2010-10-20
Genetic regulation of the end-stage clotting process that leads to thrombotic stroke
ID: 5268
Start date: 2005-01-01, End date: 2008-06-30
Thrombotic stroke is a disabling condition - affecting an estimated 650,000 Europeans annually, with considerable mortality and costing over ¬30 billion/yr. Genetic factors account for a substantial component of the incidence & mortality of stroke. There is little effective th...
Record Number: 74043
Last updated on: 2013-03-26
Autoimmune polyendocrine syndrome type I - a rare disorder of childhood as a model for autoimmunity
ID: 5223
Start date: 2005-05-01, End date: 2008-04-30
Autoimmune polyendocrine syndrome type I (APS I), a rare genetic disorder of childhood, has proven to be an invaluable tool in understanding autoimmune reactions. APS I (OMIM 240300), also known as APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy), is a s...
Record Number: 75913
Last updated on: 2009-12-14
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List retrieved on: 2018-03-23
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