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Final Report Summary - BROWSE (Bystanders, Residents, Operators and WorkerS Exposure models for plant protection products)
Executive Summary:The BROWSE project, supported by the EU 7th Framework Programme, has:• Reviewed, improved and extended the models currently used in the risk assessment of plant protection products (PPPs) to evaluate the exposure of operators, workers, residents and...
Record Number: 157865
Last updated on: 2015-03-25
KFKI general application of calibration techniques
The main activities of our institution directed to compile the scientific results achieved by other project partners and summarize the outcomes from the point of view of their possible applications. The main goal of the project was to improve the in vivo and bioassay monitorin...
Programme: FP5-EAECTP C
Record Number: 39503
Last updated on: 2010-03-08
Electronic database of information relating to the biokinetics of radionuclides after entry to the body by inhalation, ingestion or injection
The consortium collated and analysed information from the literature on experimental studies relating to the biokinetics of radioactive compounds. A wide range of radionuclides was covered, with emphasis on the actinides (e.g. uranium, plutonium), fission products (e.g. caesiu...
Programme: FP5-EAECTP C
Record Number: 44725
Last updated on: 2008-12-23
A bystander effect was found in co-cultured malignant trophoblast Jeg3 cells after 5 Gy X-rays using activation of p53 as endpoint
To study bystander effects, co-culture protocols were applied to examine the development of G2-arrest and the activation of p53 in a number of cell lines that were extensively characterized in term of their ability to establish gap juctional intercellular communication. A deta...
Programme: FP5-EAECTP C
Record Number: 44730
Last updated on: 2007-12-12
Cytogenetic experiments failed to detect clear evidence for a negative bystander response in human lymphocytes cultured with irradiated cells
Irradiated Go lymphocytes were fused to exponentially growing CHO cells and cultured for up to 30h. In the hybrid cells, lymphocyte PCCs were induced when CHO entered mitosis. Cells were harvested at various times after cell fusion using shake off and subsequently chromosome p...
Programme: FP5-EAECTP C
Record Number: 44729
Last updated on: 2007-12-12
No negative bystander effects were observed for human cells (HSF) exposed to either 4.5MeV alpha particles or 10MeV protons using a microbeam
In order to study the parameter of LET and cell type on the development of bystander effects using cell survival as endpoint, we carried out experiments with primary human skin fibroblasts (HSF2). Using 4.5MeV alpha particles (LET = 100keV/µm) we were unable to measure bystand...
Programme: FP5-EAECTP C
Record Number: 44728
Last updated on: 2007-12-12
Effects of telomerase and telomere length on epidermal stem cell behaviour
In the past, Maria Blasco and her team have shown that mice with critically short telomeres are highly sensitive to ionising radiation, i.e. show increased chromosomal instability upon gamma irradiation. More recent results shed light on the mechanism underlying telomere-drive...
Programme: FP5-EAECTP C
Record Number: 44389
Last updated on: 2007-08-22
Mouse models of telomerase overexpression
In the past, Maria Blasco and her team (partner CNIO) have shown that the telomerase reverse transcriptase component (Tert) may favour growth and survival independently of telomere length maintenance. They have generated two mouse models that over-express Tert under the kerati...
Programme: FP5-EAECTP C
Record Number: 44388
Last updated on: 2007-08-22
Role of DNA repair proteins in telomere function
To further define the role of DNA repair proteins in telomere function and telomere-driven radiosensitivity, Maria Blasco and her team (partner CNIO) has studied cells from mice deficient for the DNA repair proteins Ku86, DNA-PKcs, and PARP-1. Previous work of partner CNIO sho...
Programme: FP5-EAECTP C
Record Number: 44386
Last updated on: 2007-08-22
Novel mechanisms of telomere maintenance
During the progression of Telosens work, novel mechanisms of telomere maintenance were identified. Previous work of Maria Blasco and her team (partner CNIO) provide evidence for the implication of epigenetic mechanisms in the regulation of mammalian telomere length and functio...
Programme: FP5-EAECTP C
Record Number: 44387
Last updated on: 2007-08-22
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List retrieved on: 2018-05-22
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