Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Results 1 - 10 of 2097
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Final Report Summary - OPTOLOCO (Dynamic sensory-motor integration  in spinal circuits)
While researchers previously believed that sensory neurons were restrained to the periphery and excluded from the spinal cord, we discovered a novel sensory-motor loop in the vertebrate spinal cord itself (Bohm, Prendergast et al., Nature Communications 2016). We showed that...
Programme: FP7-IDEAS-ERC
Record Number: 228554
Last updated on: 2018-05-15
Final Report Summary - PRIME-A-PLANT (Priming of plant immunity: from its onset to trans-generational maintenance.)
Plants have the ability to increase the responsiveness of their innate immune system after perception of resistance-inducing signals from their environment. This priming of plant immunity provides broad-spectrum protection against pests and diseases, providing potential for...
Programme: FP7-IDEAS-ERC
Record Number: 228548
Last updated on: 2018-05-15
Final Report Summary - SYNAPSECODE (Uncovering the role of new synaptic adhesion molecules in encoding synaptic connectivity in the brain)
The network of neurons in our brain encodes our thoughts, memories, and personalities. Neurons are precisely connected via specialized contacts called synapses, which mediate information transfer between neurons. Perturbations in synaptic connectivity are thought to underlie...
Programme: FP7-IDEAS-ERC
Record Number: 228564
Last updated on: 2018-05-15
Final Report Summary - NERCOMP (Structural studies of Nucleotide Excision Repair complexes)
DNA (deoxyribonucleic acid) is a very long molecule present in living cells that encodes a blueprint for each organism. This blueprint is termed genetic information. DNA has two strands encoding mirror images of the same information. It constantly undergoes chemical damage...
Programme: FP7-IDEAS-ERC
Record Number: 228539
Last updated on: 2018-05-15
Final Report Summary - METABOP53 (Metabolic functions of p53 in non-cancer pathologies)
The p53 protein plays an important role in tumour suppression, with almost all cancers showing loss of normal p53 function. p53 helps cells detect and respond to stress, and our work has shown that there can be diverse outcomes to p53 activation. Under conditions of extreme or...
Programme: FP7-IDEAS-ERC
Record Number: 228566
Last updated on: 2018-05-15
Final Report Summary - PARASITENUTRISENSING (Nutrient sensing by parasites)
Despite renewed eradication efforts from the international community, malaria still exerts an enormous disease burden, with nearly half the planet’s population at risk of infection. Within the human host, the disease-causing Plasmodium parasites pass through two distinct...
Programme: FP7-IDEAS-ERC
Record Number: 228535
Last updated on: 2018-05-15
Final Report Summary - RETRAIN (REwiring the nucleus TowaRds plant ImmuNity)
Pathogens greatly hamper food production but only a few microbes can form intimate associations with plants. Plant Pattern Recognition Receptors perceive Microbe or Pathogen Associated Molecular Patterns (PAMPs) and activate Pattern Triggered Immunity. Pathogens perturb these...
Programme: FP7-IDEAS-ERC
Record Number: 228533
Last updated on: 2018-05-15
Final Report Summary - STARLIN (Cell migration in gut homeostasis and cancer invasion - role of microenvironment)
The entire intestinal epithelium is renewed every week due to cell division in the crypts coupled with cell migration towards the villi and loss of cells by apoptosis at the tip of villi. However, the mechanism responsible for the migration of intestinal cells remains largely...
Programme: FP7-IDEAS-ERC
Record Number: 228521
Last updated on: 2018-05-15
Final Report Summary - BRAINGUTTALK (Brain-gut interactions in Drosophila melanogaster)
Our gastrointestinal tract is populated by millions of nerve cells, yet we know relatively little about what all these nerve cells do. Fruit flies have guts and nerve cells which, unlike ours or those of other animals, are relatively easy to manipulate by turning their genes...
Programme: FP7-IDEAS-ERC
Record Number: 228474
Last updated on: 2018-05-15
Final Report Summary - ATMINDDR (ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN)
We have made several notable discoveries relating to the discovery of novel ATM signalling pathway components and the molecular basis for ATM pathway selectivity. Our previous work has shown that ATM signalling is mediated by 2 distinct pathways, the MRN-dependent pathway, and...
Programme: FP7-IDEAS-ERC
Record Number: 228385
Last updated on: 2018-05-15
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List retrieved on: 2018-05-24
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