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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Results 1 - 10 of 632
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Hypothalamic Lipotoxicity and Endoplasmic Reticulum Stress: a New Pathophysiological Mechanism of Obesity
ID: 281854
Start date: 2011-12-01, End date: 2017-05-31
It is well established that metabolically relevant organs such as adipose tissue, pancreatic beta cells, liver and skeletal muscle develop endoplasmic reticulum (ER) stress under conditions of obesity induced lipotoxicity. Here, the applicant will investigate if/how the hypot...
Programme: FP7-IDEAS-ERC
Record Number: 100682
Last updated on: 2018-01-22
Science and technology development for in situ detection and cjharacterization of subsurface life on the Iberian Pyritic Belt
ID: 250350
Start date: 2010-06-01, End date: 2015-05-31
Terrestrial subsurface geomicrobiology is a matter of growing interest on many level. From a fundamental point of view, it seeks to determine wheter life can be sustained in the absence of radiation. From an astrobiological point of view, it is an interesting model for early ...
Programme: FP7-IDEAS-ERC
Record Number: 94586
Last updated on: 2018-01-22
p53 as a New Mediator of Energy Balance in the Brain
ID: 281408
Start date: 2011-12-01, End date: 2017-05-31
p53 is a transcriptional factor modulating numerous biological actions. Although it is best known for its role in cancer development, it is now evident that it is implicated in metabolism. More specifically, p53 modulates energy metabolism and homeostasis through their effect...
Programme: FP7-IDEAS-ERC
Record Number: 100931
Last updated on: 2018-01-03
Systematic investigation of epistasis in molecular evolution
ID: 335980
Start date: 2014-01-01, End date: 2018-12-31
Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictio...
Programme: FP7-IDEAS-ERC
Record Number: 111571
Last updated on: 2017-12-18
Wiring up visual circuits: Interplay between gene expression and spontaneous and experience-dependent activity
ID: 282329
Start date: 2012-01-01, End date: 2017-06-30
A fundamental feature of the developing neural circuits is their ability to change in response to sensorial experience. This phenomenon has been particularly observed during the generation of cortical maps, where altering the pattern of sensory experience changes the spatial ...
Programme: FP7-IDEAS-ERC
Record Number: 101546
Last updated on: 2017-12-18
Engineering an artificial immune system with functional components assembled from prokaryotic parts and modules
ID: 322797
Start date: 2013-05-01, End date: 2019-04-30
The objective of this project is to overcome current limitations for antibody production that are inherent to the extant immune system of vertebrates. This will be done by creating an all-in-one artificial/synthetic counterpart based exclusively on prokaryotic parts, devices ...
Programme: FP7-IDEAS-ERC
Record Number: 107706
Last updated on: 2017-12-07
Teleost B lymphocytes, the equivalent of mammalian B1 innate lymphocytes?
ID: 280469
Start date: 2011-12-01, End date: 2016-11-30
Teleost fish are the most primitive bony vertebrates that contain immunoglobulins, although belonging to different classes than those of mammals, having only IgM, IgD and IgT. No Ig maturation to more specific class is observed in fish, providing them with an antibody respons...
Programme: FP7-IDEAS-ERC
Record Number: 101234
Last updated on: 2017-12-04
A systems pharmacology approach to the discovery of novel therapeutics in Alzheimer´s disease
ID: 614944
Start date: 2014-04-01, End date: 2019-03-31
Alzheimer´s disease (AD) is the most common form of dementia, with over 35 million people suffering from it worldwide, and it constitutes a personal and societal tragedy of immense proportions. Fifty years of intense research have revealed many key elements of the biology of ...
Programme: FP7-IDEAS-ERC
Record Number: 185567
Last updated on: 2017-11-20
Variability in the mutation rate of RNA viruses
ID: 281191
Start date: 2012-01-01, End date: 2016-12-31
RNA viruses are the fastest evolving entities in nature. Such rapid evolution is explained by their mutation rates, which are orders of magnitude higher than those of DNA organisms. The error-prone replication of RNA viruses also has public-health implications related to path...
Programme: FP7-IDEAS-ERC
Record Number: 100902
Last updated on: 2017-11-20
Mechanisms and Targeting Stromal Contribution to Tumour Invasion and Metastasis
ID: 281830
Start date: 2012-06-01, End date: 2017-05-31
Angiogenesis inhibition has proven to be a successful anti-cancer therapeutic approach and anti-angiogenic therapies are currently approved as standard therapy in several types of cancer for their clinically validated beneficial extension of overall survival, progression-free...
Programme: FP7-IDEAS-ERC
Record Number: 103846
Last updated on: 2017-11-20
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List retrieved on: 2018-08-16
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