Community Research and Development Information Service - CORDIS

Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Quantitative Molecular Map of the Neuronal Surface
ID: 293681
Start date: 2012-02-01, End date: 2017-01-31
The most fundamental roles of nerve cells are the detection of chemical neurotransmitters to generate synaptic potentials; the summation of these potentials to create their output signals; and the consequent release of their own neurotransmitter molecules. All of these functi...
Programme: FP7-IDEAS-ERC
Record Number: 102234
Last updated on: 2017-12-04
Cortical circuits of visual perception
ID: 281885
Start date: 2012-01-01, End date: 2016-12-31
Active perception relies on the concerted activity of populations of neurons in the cerebral cortex. These neuronal populations communicate via dense local and long-range connections, forming complex cortical circuits. While we are beginning to understand the elementary build...
Programme: FP7-IDEAS-ERC
Record Number: 100919
Last updated on: 2017-12-04
Chromatin and transcription in ES cells: from single cells to genome wide views
ID: 281781
Start date: 2011-12-01, End date: 2016-11-30
How embryonic stem cells (ESCs) maintain their dual capacity to self-renew and to differentiate into all cell types is one of the fundamental questions in biology. Although this question remains largely open, there is growing evidence suggesting that chromatin plasticity is a...
Programme: FP7-IDEAS-ERC
Record Number: 101022
Last updated on: 2017-12-04
Structural Biology of Mitochondrial Outer Membrane Proteins
ID: 281764
Start date: 2011-12-01, End date: 2016-11-30
To elucidate the biological role of the mitochondrial outer membrane (MOM), I propose to determine structures and functions of integral MOM protein complexes at atomic resolution, involving the three proteins VDAC, Bax and Sam. These are key elements of vital cellular functio...
Programme: FP7-IDEAS-ERC
Record Number: 100531
Last updated on: 2017-12-04
Exploitation of actinomycetes genomics using synthetic and system biology approaches
ID: 281623
Start date: 2012-01-01, End date: 2016-12-31
"Actinomycetes produce a wealth of important natural products, which play a pivotal role in modern drug-based therapy of various diseases. Recent whole-genome sequencing projects have revealed that the number of biosynthetic gene clusters significantly outnumbers the natural ...
Programme: FP7-IDEAS-ERC
Record Number: 100640
Last updated on: 2017-12-04
NMD Complexes: Eukaryotic mRNA Quality Control
ID: 281331
Start date: 2012-02-01, End date: 2016-11-30
Nonsense-mediated mRNA decay (NMD) is an essential mechanism controlling translation in the eukaryotic cell. NMD ascertains accurate expression of the genetic information by quality controlling messenger RNA (mRNA). During translation, NMD factors recognize and target to degr...
Programme: FP7-IDEAS-ERC
Record Number: 100402
Last updated on: 2017-12-04
Harnessing systems immunology to unravel dendritic cell subset biology
ID: 281225
Start date: 2012-02-01, End date: 2017-07-31
The development of better vaccines against cancer or intracellular pathogens is a major challenge of immunological research. Novel approaches are needed to induce efficient, long-lasting memory CD8 T cell (CTL) responses. The CD8α subset of mouse dendritic cells (mDC) is spec...
Programme: FP7-IDEAS-ERC
Record Number: 101849
Last updated on: 2017-12-04
Sex-specific genetic effects on fitness and human disease
ID: 280632
Start date: 2012-01-01, End date: 2016-12-31
Darwin’s theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary bio...
Programme: FP7-IDEAS-ERC
Record Number: 101182
Last updated on: 2017-12-04
Teleost B lymphocytes, the equivalent of mammalian B1 innate lymphocytes?
ID: 280469
Start date: 2011-12-01, End date: 2016-11-30
Teleost fish are the most primitive bony vertebrates that contain immunoglobulins, although belonging to different classes than those of mammals, having only IgM, IgD and IgT. No Ig maturation to more specific class is observed in fish, providing them with an antibody respons...
Programme: FP7-IDEAS-ERC
Record Number: 101234
Last updated on: 2017-12-04
Single-Molecule BioAssays at Elevated Concentrations
ID: 261162
Start date: 2010-11-01, End date: 2016-10-31
In order to advance single-molecule fluorescence spectroscopy to the next level, handling and analysis of single molecules has to become broadly available. A further quantum leap is required to proceed to commercially successful applications such as drug screening and medical...
Programme: FP7-IDEAS-ERC
Record Number: 96689
Last updated on: 2017-12-04
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List retrieved on: 2018-02-21
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