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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Engineering an artificial immune system with functional components assembled from prokaryotic parts and modules
ID: 322797
Start date: 2013-05-01, End date: 2019-04-30
The objective of this project is to overcome current limitations for antibody production that are inherent to the extant immune system of vertebrates. This will be done by creating an all-in-one artificial/synthetic counterpart based exclusively on prokaryotic parts, devices ...
Programme: FP7-IDEAS-ERC
Record Number: 107706
Last updated on: 2017-12-07
Teleost B lymphocytes, the equivalent of mammalian B1 innate lymphocytes?
ID: 280469
Start date: 2011-12-01, End date: 2016-11-30
Teleost fish are the most primitive bony vertebrates that contain immunoglobulins, although belonging to different classes than those of mammals, having only IgM, IgD and IgT. No Ig maturation to more specific class is observed in fish, providing them with an antibody respons...
Programme: FP7-IDEAS-ERC
Record Number: 101234
Last updated on: 2017-12-04
Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes
ID: 258967
Start date: 2011-01-01, End date: 2018-06-30
Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components. While there are several ongoing large-scale genome re-sequen...
Programme: FP7-HEALTH
Record Number: 97660
Last updated on: 2017-07-16
Epigenetics towards systems biology
[PROJECT] EPIGENESYS - Epigenetics towards systems biology
ID: 257082
Start date: 2010-10-01, End date: 2016-03-31
The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epige...
Programme: FP7-HEALTH
Record Number: 97509
Last updated on: 2017-06-12
Epigenetic Disruption of Non-Coding RNAs in Human Cancer
ID: 268626
Start date: 2011-04-01, End date: 2016-03-31
In recent years, my laboratory, as well as others, have established the observation that epigenetic disruption, particularly in the DNA methylation and histone modification patterns, contributes to the initiation and progression of human tumors (Esteller, Nat Rev Genet 2007; ...
Programme: FP7-IDEAS-ERC
Record Number: 98545
Last updated on: 2017-05-26
Functional characterization of plant cellular IRES  in response to abiotic stress and their use as  biotechnological tools
ID: 260468
Start date: 2010-12-01, End date: 2017-05-31
To cope with abiotic stresses plants require an extensive molecular regulation of gene expression. In plants, translation is a key step in the control of gene expression under abiotic stress conditions. This translational regulation involves (1) a global inhibition of protein...
Programme: FP7-IDEAS-ERC
Record Number: 97065
Last updated on: 2017-05-26
Ras Genes in Health and Disease
[PROJECT] RAS AHEAD - Ras Genes in Health and Disease
ID: 250297
Start date: 2010-04-01, End date: 2015-03-31
Ras genes are some of the best-studied genes in biomedical research due to their central role in mitogenic signaling and their oncogenic activation in one third of all human tumors. More recently, Ras genes have also been implicated in developmental disorders including Costel...
Programme: FP7-IDEAS-ERC
Record Number: 94154
Last updated on: 2017-05-26
OVErcoming Resistance to anti-HER2 therapy
ID: 250244
Start date: 2011-01-01, End date: 2014-12-31
HER2 is a membrane receptor tyrosine kinase overexpressed in 30% of breast tumors and results in an aggressive clinical course. Anti-HER2 therapies including monoclonal antibodies (trastuzumab) and small-molecule tyrosine kinase inhibitors (lapatinib) are active and have impr...
Programme: FP7-IDEAS-ERC
Record Number: 97315
Last updated on: 2017-05-26
Development of super-wheat crops by introgressing agronomic traits from related wild species
ID: 243118
Start date: 2010-01-01, End date: 2015-12-31
Wheat is one of the most important food crops in the world and understanding its genetics and genome organisation is of great value for genetics and plant breeding purposes. Despite is genome complexity (polyploidy), hexaploid and tetraploid wheats behave as diploids during m...
Programme: FP7-IDEAS-ERC
Record Number: 92727
Last updated on: 2017-05-25
AP-1 (Fos/Jun) Functions in Physiology and Disease
ID: 233294
Start date: 2009-11-01, End date: 2015-10-31
Our research interests lie in breaking new ground in studying mechanism-based functions of AP-1 (Fos/Jun) in vivo with the aim of obtaining a more global perspective on AP-1 in human physiology and disease/cancer. The unresolved issues regarding the AP-1 subunit composition w...
Programme: FP7-IDEAS-ERC
Record Number: 92530
Last updated on: 2017-05-25
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List retrieved on: 2018-06-23
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