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Factor XII and the contact system: 
cross-talk between thrombosis and inflammation
ID: 311575
Start date: 2013-08-01, End date: 2018-07-31
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of proc...
Programme: FP7-IDEAS-ERC
Record Number: 109422
Last updated on: 2018-01-22
Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function
ID: 311335
Start date: 2013-05-01, End date: 2018-04-30
Human primary immunodeficiencies affecting cytotoxic lymphocyte function are associated with high morbidity and mortality. They often present as hyperinflammatory syndromes triggered by viral infections, hematological malignancies, or systemic autoimmunity. Although recent ad...
Programme: FP7-IDEAS-ERC
Record Number: 108234
Last updated on: 2018-01-22
Hypothalamic Lipotoxicity and Endoplasmic Reticulum Stress: a New Pathophysiological Mechanism of Obesity
ID: 281854
Start date: 2011-12-01, End date: 2017-05-31
It is well established that metabolically relevant organs such as adipose tissue, pancreatic beta cells, liver and skeletal muscle develop endoplasmic reticulum (ER) stress under conditions of obesity induced lipotoxicity. Here, the applicant will investigate if/how the hypot...
Programme: FP7-IDEAS-ERC
Record Number: 100682
Last updated on: 2018-01-22
Disarming bacterial weapons in the nucleus:
functional study of Chlamydia nuclear effectors
ID: 282046
Start date: 2012-07-01, End date: 2018-06-30
The high prevalence of Chlamydia infections and the heavy burden they inflict on public health justify the search for novel therapeutic approaches directed against this pathogen. Research on this obligate intracellular bacterium is very difficult, due to substantial technical...
Programme: FP7-IDEAS-ERC
Record Number: 103960
Last updated on: 2018-01-15
A radical approach for improved glaucoma treatment
ID: 322656
Start date: 2013-04-01, End date: 2018-09-30
Open angle glaucoma (OAG) is the second leading cause of world blindness. Treatments involving topically applied pressure-reducing medications or surgery targeting ocular drainage channels are effective, although significant complications exist. We propose to address the hypo...
Programme: FP7-IDEAS-ERC
Record Number: 107669
Last updated on: 2018-01-08
Dynamics of human genome architecture in stable and transient gene expression changes
ID: 609989
Start date: 2014-06-01, End date: 2019-05-31
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the...
Programme: FP7-IDEAS-ERC
Record Number: 191292
Last updated on: 2018-01-03
Updating the mind: The mechanisms behind behavioural change
ID: 312445
Start date: 2013-02-01, End date: 2018-01-31
Translation of basic research on human executive control into facilitating behavioural change is a holy grail for psychologists and neuroscientists. Adaptive behaviour is attributed to executive functions that update the cognitive system. But how system updating mechanisms re...
Programme: FP7-IDEAS-ERC
Record Number: 105964
Last updated on: 2018-01-03
Bi-literacy: Learning to read in L1 and in L2
ID: 295362
Start date: 2012-05-01, End date: 2017-04-30
Learning to read is probably one of the most exciting discoveries in our life. Using a longitudinal approach, the research proposed examines how the human brain responds to two major challenges: (a) the instantiation a complex cognitive function for which there is no genetic ...
Programme: FP7-IDEAS-ERC
Record Number: 103543
Last updated on: 2018-01-03
p53 as a New Mediator of Energy Balance in the Brain
ID: 281408
Start date: 2011-12-01, End date: 2017-05-31
p53 is a transcriptional factor modulating numerous biological actions. Although it is best known for its role in cancer development, it is now evident that it is implicated in metabolism. More specifically, p53 modulates energy metabolism and homeostasis through their effect...
Programme: FP7-IDEAS-ERC
Record Number: 100931
Last updated on: 2018-01-03
Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells
ID: 339977
Start date: 2014-02-01, End date: 2019-07-31
There is an urgent need to develop vaccines for the induction of CD8+ T-cell immunity to treat cancer and infectious diseases. Dendritic Cells (DC) have shown potential to induce antigen specific CD8+ T-cell responses with the help of CD4+ T cells, yet the efficacy by which t...
Programme: FP7-IDEAS-ERC
Record Number: 192378
Last updated on: 2017-12-18
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List retrieved on: 2018-03-20
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