Community Research and Development Information Service - CORDIS


Final Report - PI3K/ONCOGENESIS (The role of p110alpha isoform of PI 3-kinase in oncogenesis and cellular senescence)

Project ID: 219945
Funded under: FP7-PEOPLE


This is an attachment to the final report of the EU-funded PI3K/ONCOGENESIS project, which aimed to identify the role of p110alpha isoform of PI3 kinase in oncogenesis and cellular senescence. The document contains numerous explanatory figures based on the project findings that were derived through mice experiments. The inactivation of p110alpha or beta did not affect the survival of Pten mice, for which a tumour spectrum is provided. The gene targeting strategy that was applied is also depicted as well as the method used for the generation of p110alpha mice. Other figures include several observations, such as the lethality of oncogenic p110alpha H1047R, the increased apoptosis that was noted in several mutant embryos, or the behaviour of the hypomorphic allele.

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