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Final Report - Emergence (Building a regulatory network for lateral root emergence)

Project ID: 220506
Funded under: FP7-PEOPLE


Cell separation is a critical process for plants. Germinating seedlings emerge from their seed coats, anthers dehisce, fruit ripen, and organs are shed as a result of plant cell separation. To date, several cell wall remodelling enzymes associated with cell separation have been identified; however, very little is known about the signals and mechanisms controlling their expression. The host laboratory has recently made major advances in the identification of the signals and molecular mechanisms regulating cell separation during lateral root emergence.

The EMERGENCE project aimed at identifying the molecular events underlying this process in order to build a multiscale model of lateral root emergence. The goal of their modelling approach was to:
1) build a network model of LAX3 induction in the cortical cells to determine if the actual network topology can explain the dynamics of LAX3 induction by auxin;
2) integrate the network into a realistic 3D geometry to characterise the spatial induction of LAX3; and
3) to determine whether our model could predict new important components of the LR emergence pathway.

The final report explains how their initial hypothesis were being confirmed through observations by performing yeast-one hybrid experiments. Interestingly, the project showed that they can perturb the output of the network by using different mutants: some mutants completely block the lateral root emergence network, while others impact the strength of the signal and others modify the timing of the response.

Images are also included.

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