Community Research and Development Information Service - CORDIS


Final Report - NMRPAMS (NMDA receptor processing in an animal model for schizophrenia)

Project ID: 231108
Funded under: FP7-PEOPLE


This is the final report of the NMRPAMS project which used an animal model to study changes in early events associated with alternative splicing, assembly and trafficking of new NR2A and NR2B receptors in schizophrenia. This is a comprehensive summary overview of results, conclusions and the socio-economic impacts of the project. The report concludes with some of their results. It notes that selectively altered expression of the NR2B NMDA receptor subtype in prefrontal cortex in animals with PCP induced reductions in cognitive ability indicates the involvement of this receptor subtype and cortical area in higher cognitive processing. This has direct relevance to better understanding of the changes that occurs in patients with schizophrenia and the present results therefore will inform at a molecular level to potential ways signalling is altered in this psychiatric illness.

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