Community Research and Development Information Service - CORDIS


Final Report - SURUCO (Sugar-linked ruthenium-anticancer complexes)

Project ID: 220890
Funded under: FP7-PEOPLE


This is the periodic report for 'Sugar-linked ruthenium-anticancer complexes' (SuRuCo). In recent years, ruthenium(II)- and osmium(II)-arene complexes have become the focus of interest and some examples appear to be promising anticancer drug candidates. The metal-arene motif is an excellent scaffold for rational drug design, with the potential to fine-tune the anticancer activity and other drug-relevant properties such as stability and solubility.

While the ruthenium(II) and osmium(II)-arene complexes were not strongly cytotoxic the cluster compounds showed exceptionally high cytotoxicity on the human A2780, A2780cisR ovarian carcinoma cell lines. Such high cytotoxicity in the case clusters with one or two sugar ligands may be explained by the presence of an unsubstituted ruthenium centre and the possible interaction of this centre with biological targets and also due to carbon monoxide releasing properties. The CO releasing potential was studied by myoglobin assay and energy-dependent electrospray ionisation mass spectrometry (EDESI) showing stepwise loss of CO.

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