Community Research and Development Information Service - CORDIS


Final Report - NEURAL CIRCUITS (Functional analysis of genetically identified retinal interneurons)

Project ID: 221700
Funded under: FP7-PEOPLE


Retinal processing in known to change during different ambient light conditions. In particular, the different photoreceptor dominate the transformation of light energy into neural signals. Rods operate at low light levels, while cones dominate during daylight conditions. Aside from the use of different photoreceptors the receptive field properties of retinal ganglion cells, the output of the retina, are known to change with the ambient light level. In particular, the cells selectivity for different spatial frequencies.

The NEURAL CIRCUITS project has uncovered a neural circuit capable of switching on the inhibitory surround of a neuron in a input state dependent manner. Specifically, the project partners have been able to describe the circuitry that mediates the breakdown of the centre-surround receptive field organisation of retinal ganglion cells in scotopic conditions. The report includes images and stresses that their work suggests a neural circuit switch that turns on a widefield GABAergic amacrine cell via electrical coupling with ON cone bipolar cells and is toggled by the activation of cones.

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