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Final Report - HIV TRAFFIC CONTROL (The role of centrosomes in HIV cytoplasmic transport)

Project ID: 220092
Funded under: FP7-PEOPLE


The objective of the project was to understand the role of the centrosome in the life cycle and assembly process of the human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). The aims were to delineate the viral and host factors, which define this interaction and to seek promising drug targets for novel antiviral approaches to HIV. A number of stages in the HIV life cycle were targeted for therapeutic attack. Recent evidence concerning early stages of assembly implicates the centrosome of the cell and some highly conserved viral components.

The methods involved were in vivo imaging, including selected mutants of the virus, and genetic and biochemical analyses. The report includes a graphic representation of the overview of HIV-1 RNA biology, visualisation of centrosomes in HIV-1-producing cells as well as figures of knock-down of kinesins differentially affects production of HIV-1 infectious particles and cell-viability upon siRNA transfection.

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