Community Research and Development Information Service - CORDIS


Final Report - DENDRITE (Deposition of encapsulated network of drugs to prevent remedial implant treatment emanating from deep bone infection)

Funded under: FP6-SME


Hip and knee implantation are amongst the most common operations carried out in the EC today. In Europe there are currently over 800 000 knee operations per year and the rate is increasing by 15 % p.a. meaning that by 2015 the number of operations being performed will have reached 3.2 m. The main reasons for knee replacement surgery vary from correction of a birth defect or deformity to damage caused during an injury but also osteoarthritis.

This report covers the work carried out from month 0 to month 28 of the project. The main body of this report is, at the request of the industrial partners, an overview. However, more detailed appendices are attached to cover the work programme, and the reports on specific task deliverables.

The proposed CRAFT research project, DENDRITE, proposes to develop a surface coating for prosthesis implants such as hip and knee implants that will release drugs for the promotion and early fixation of the implants and for the prevention of infections. This will be done by the incorporation of a surface coating that will have both free form hydroxyapatite and polymer encapsulated antibiotic drugs and bone promotion agent that will be released over a time period.

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