Community Research and Development Information Service - CORDIS


Final Report - PAINGENES (Heritability of chronic neuropathic pain)

Project ID: 502800


Chronic pain undermines the health and welfare of millions of EU citizens and carries enormous financial costs. Individual variability in the burden of pain has traditionally been attributed to psychosocial factors. However, new data indicate that there is an important heritable predisposition to pain, particularly to the development of chronic pain after neural injury (neuropathic pain). Pain susceptibility genes are intrinsically hard to detect in human lineages and populations.

The PAINGENES project exploited new rodent models of neuropathy to uncover pain-related genetic loci and associated neurobiological processes in inbred mouse strains that show high versus low pain susceptibility. Overall according to their report, very satisfying progress was made. Ultimately, their report concludes that it has contributed substantially to the body of knowledge on pain genetics, with ultimate benefits for pain sufferers, their families, employers and European economies.

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