Community Research and Development Information Service - CORDIS


Final Report - IMPACTS (Archive's tissues: improving molecular medicine research and clinical practice')

Project ID: 37211


The development of molecular medicine relies largely upon availability of human tissues, for validation of biomarkers used for diagnosis, prognosis and therapy. A huge quantity of tissues affected by any kind of diseases is stored in the pathology archives of any hospital. Tissue biopsies or surgical specimens are fixed and paraffin-embedded for routine practice to obtain histological sections for a final diagnosis and staging of the diseases. After a few sections are cut, the tissues are stored for decades in the hospital archives.

According to their final report the group has validated and standardised these molecular methods, in DNA and RNA analysis, and specific guidelines have been prepared and discussed for clinical application. This step is extremely important to be able to diffuse the methods at the European level for a clinical application. The group has also studied innovative techniques such as new fixatives that are preserving macromolecules, e.g. proteins, in the same way as in fresh frozen tissues.

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