Community Research and Development Information Service - CORDIS


Final Report - SPASTICMODELS (Genetic Models of Chronic Neuronal Degeneration Causing Hereditary Spastic Paraplegia)

Project ID: 503382


This is the final report for the BIOBRIDGE project which sought to enhance the biomedical understanding of the underlying mechanisms explaining the systemic effects of the target disorders. The report notes that the main achievements in this field were those related with:
- multilevel data integration;
- development of SBML standards ensuring interoperability among different ICT tools;
- development of deterministic modelling of oxygen transport-central metabolism and mitochondrial ROS generation;
- preparing tools for inference analysis and probabilistic modelling; and
- integration of simulation environment into the BIOBRIDGE portal.

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