Community Research and Development Information Service - CORDIS


Final Report - APOTHERAPY (CD40 ligand-based modalities for the treatment of solid tumours)

Project ID: 37344


This is the final report for the APOTHERAPY project which aimed to research the utilisation of combined approaches which attack the tumour cell at multiple levels, achieving maximal apoptosis while limiting the risk of drug resistance. These approaches involve the efficient delivery of a pro-apoptotic molecule to cancer cells in combination with inhibitors of anti-apoptotic signal transduction pathways.

The project has led to small-scale clinical studies in patients with bladder cancer which have demonstrated the feasibility and validity of the APOTHERAPY concept and paved the way for future phase 1 clinical trials.

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