Community Research and Development Information Service - CORDIS


Final Report - IMMUNOVACTB (A new approach for developing a less immunosuppressive tuberculosis vaccine)

Project ID: 37388


This is the final report for the IMMUNOVACTB. Infections due to Mycobacterium tuberculosis cause over two million deaths each year. A major problem in combating tuberculosis is insufficient efficacy of the current vaccine, M. bovis BCG.

The project attempted to isolate BCG strains that lack the LAM mannose cap (or parts thereof) and / or cannot produce PGL. It is hoped that the new and improved insight will also be gained into how the immune system is manipulated by mycobacterial glycolipids, with the aim of developing an improved M. bovis BCG vaccine.

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