Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS


Final Report - PLASMODIUMDUTPASE (Deoxyuridine Triphosphate Nucleotidohydrolase as a Drug Target against Malaria)

Project ID: 37587


This is the final report of the PLASMODIUMDUTPASE project. The aim was to optimise early lead molecules in order to generate advanced leads or preclinical drug candidates. The project prepared and investigated a wide variety of chemical types for inhibition of both the parasite enzyme, dUTPase, and the intact parasite. They developed potent and selective inhibitors of the enzyme as well as developed potent and selective inhibitors of parasite growth. The compounds are still in the process of optimisation. Further work is required to optimise these compounds to the level of preclinical candidates.

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