Community Research and Development Information Service - CORDIS


Final Report - COMBIG-TOP (Combinatorial Biosynthesis of Industrial Glycopeptides: Technology, Optimization and Production)

Project ID: 503491


This is the final report of the COMBIG-TOP project, which aimed to integrate industrial and academic laboratories in a combined research and development (R&D) effort directed at generating new drug candidates, and providing effective and general tools for faster development of current pre-market drugs. The report reveals that one of the main issues in speeding up the development of a new drug is an efficient supply of compounds by improvement of the producing strain, the fermentation process and/or the recovery of the active principle. For this reason, the physiology of the producing strain was investigated in detail. The availability of genomic data allowed comparisons with other actinomycetes, which in turn offered new insights into the requirements of an ideal host for glycopeptide production.

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