Community Research and Development Information Service - CORDIS


Final Report - SYNSCAFF (Synaptic scaffolding proteins orchestrating cortical synapse organisation during development)

Project ID: 511995


This is the final report of the SYNSCAFF project which aimed at reaching a more comprehensive understanding of cortical networking during development and in particular of genes and their products governing the complex molecular mechanisms driving synaptic structuring and organisation during development of cortical networks and circuitries. As outlined in the report this project integrated the information about the role of different candidate genes / proteins in synaptic formation, remodelling and function and it capitalises on results obtained in in vitro systems and translated them to increase our knowledge on mental retardation, identifying both key steps responsible for defect of development and new genes / proteins and mechanisms responsible for a defect in development.

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