Community Research and Development Information Service - CORDIS


Final Report - SFMET (HGF/SF and MET in metastasis)

Project ID: 201640
Funded under: FP7-HEALTH


This is the final activity report of the 'SFMET' project, which was funded under the European Community's Seventh Framework Programme and aimed to understand how the growth and motility factor HGF/SF and its membrane receptor MET contributed to the process of tumour invasion and metastasis, as well as to determine crystal structures of the HGF/SF-MET complex and of suitably engineered fragments of HGF/SF that could compete with the natural MET ligand and thus block HGF/SF-dependent MET signalling in cancer cells.

the document provides a brief overview of the project objectives and then analyses the activities that were undertaken by the various work packages (WPs) and highlights the obtained results. Finally, the potential socioeconomic impacts of SFMET findings are presented.

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