Community Research and Development Information Service - CORDIS


Final Report - IPODD (Inflammation bowe disease(IBD): proteases offer new targets for drug discovery)

Project ID: 202020
Funded under: FP7-HEALTH


This is the final summary report of IPODD project that was launched in 2008 and funded under the European Commission (EC)'s Seventh Framework Programme (FP7).

The first introductory chapters provide general information about the inflammatory bowel disease (IBD).Additionally, the contractors involved in the project are mentioned. At the heart of this report is a description of the project's context and objectives. IPODD's work:

1. focus on matrix metalloproteases (MMPs),and their multifaceted role in IBD;
2. aims to find which proteases are present in the gut in IBD;
3. produces data to suggest that MMPs may be rejuvenated as therapeutic targets;
4. identifies the role of MMPs and their inhibitors in IBDs;
5. discovers the role of bacteria in IBD; %5. develops strategies to inhibit MMP activity in the human intestine.

The role of tumor necrosis factor (TNF) converting enzyme (TACE), a major pro-inflammatory factor, was also an important field of investigation.

The summary also includes the several initiatives , IPODD engaged in to disseminate scientific knowledge and results across the project research teams involved and the lay public.

Download application/zip (7089131)

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