Community Research and Development Information Service - CORDIS


Final Report - HISTONE DEMETHYLASES (A Chemical Genetics Approach towards Cancer Therapy Targeting Histone Demethylases)

Project ID: 298603
Funded under: FP7-PEOPLE


This is the final report for the HISTONE DEMETHYLASES project, which received funding under the Seventh Framework Programme (FP7). In this proposal an approach to validate a new class of enzymes as targets for cancer therapy is presented. In the cell nucleus, DNA is bound to special proteins, called histones, which play key roles in gene regulation. Histones can be dynamically modified with special marker groups, which allows the control of gene expression without alteration of the DNA itself. The report covers the importance of the project before going on to explain the actions undertaken and the results achieved. The report concludes by highlighting that the project resulted in potent and selective inhibitors for a specific subfamily of histone demethylases.

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