Community Research and Development Information Service - CORDIS


Final Report - ANGIOSCAFF (Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Engineering)

Project ID: 214402
Funded under: FP7-NMP


This is the final report for the ANGIOSCAFF project which was funded under the Seventh Framework Package (FP7). ANGIOSCAFF was a partnership of 33 different opinion leaders in regenerative medicine that collaborated from December 2008 to November 2012 on a portfolio of 110 portfolio projects. These projects focused on early stage preclinical development of cutting edge regenerative therapies for the eventual treatment of the major age related and genetic degenerative diseases that result in tissue dysfunctionality and decline in contribution to our society. The report begins by outlining that the whole project concept was based on combining biomaterials composed of various chemical structures with bioactive molecules known to have influence on specific tissues and then validated either with or without exogenous cells in preclinically relevant animal models, as part of a tailoring towards tissue need. The report highlights that seven different biomaterials were developed to be potentially combined with up to twenty different tissue stimulating factors. In addition to this the project's outcomes were all focused on addressing traumatic and degenerative diseases which represent a significant proportion of chronic, progressive and often fatal diseases with profound human and societal costs. Effective, applicable and reimbursable therapeutic approaches are few despite the known diseases associations with a progressive decline in tissue function that prohibit a healthy ageing.

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