Community Research and Development Information Service - CORDIS


Final Report - RHOGEFS IN EPITHELIA (The role of RhoGEFs in epithelial polarity using a three-dimensional model)

Project ID: 209382
Funded under: FP7-PEOPLE


This is the final report of the RHOGEFS IN EPITHELIA project, which is funded under the European Commission (EC) Seventh Framework Programme (FP7). Epithelial organs are made of tubes and cavities lined with a monolayer of polarised cells enclosing the central lumen. Lumen formation is a crucial step in the formation of epithelial organs. De novo epithelial lumen morphogenesis is a well-regulated process, requiring the orchestration of many different pathways in a very short time. Defects associated with these pathways lead to abnormalities in epithelial morphogenesis, and are common cause of major diseases like cancer.

Work in the project has enhanced the understanding of genetic and biochemical mechanisms that control self-renewal and asymmetric division, as well as the role of the stem cell niche in regulating the biological properties of both normal and cancer stem cells. These are key issues for the future, because preventing these abnormalities may limit the proportion of cells that fuel tumour growth in carcinomas.

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