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Final Report - YEAST SENSING (Nutrient sensing and signaling by the yeast Gap1 amino acid transceptor)

Project ID: 203103
Funded under: FP7-PEOPLE


This is the final report of the YEAST SENSING project, which is funded under the European Commission (EC) Seventh Framework Programme (FP7). The initial goal was to better understand how protein transceptors can signal the presence of nutrients in the environment to central regulatory pathways controlling cell growth and division. The study focused on the general amino acid permease and transceptor, Gap1. One important result was the discovery that three specific gamma-glutamyl dipeptides strongly enhance the proton flux while being transported by Gap1 transceptor. Another revealed the internalised Gap1 transceptor can still signal to the PKA pathway. The project identified a novel mechanism, enhanced proton influx through a proton symporter, by which these transported gamma-glutamyl dipeptides cause a defect in vacuolar sorting and the accumulation of Gap1 in endosomes.

The results show how the use of specific chemical compounds as tools for biological studies can lead to unexpected discoveries and provide novel insight into biological processes.

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