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Final Report - RODCELL (Cellular and molecular mechanisms of the light response in photoreceptor cells of the mammalian retina)

Project ID: 210042
Funded under: FP7-PEOPLE


This is the final report of the RODCELL project, which is funded under the European Commission (EC) Seventh Framework Programme (FP7). Genetic defects in proteins involved in the transduction of light in retina photoreceptor cells lead to severe retinal degeneration and blindness. The project set out to establish mouse models of the autosomal dominant cone dystrophies (adCDs) caused by mutations in the genes encoding Guanylate Cyclase Activating Protein 1 (GCAP1) and 2 (GCAP2) so as to study the routes to cell death in vivo. The second aim was to study the novel role of the Guanylate Cyclase Activating Proteins in the synaptic terminal of rod cells, where they seem to play an important role in the dynamic assembly/disassembly of synaptic ribbons with changes in illumination.

The researchers introduced innovative, more practical and affordable strategies for mouse genetics in the lab, by developing protocols of in vivo DNA electroporation to transiently or stably express heterologous DNA in murine photoreceptors.

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