Community Research and Development Information Service - CORDIS


Final Report - COMBATING SEPSIS (Why do they die? Deciphering and quelling the lethal cues of immuno-inflammatory response in sepsis.)

Project ID: 203685
Funded under: FP7-PEOPLE


This is the final report of the COMBATING SEPSIS project, which is funded under the European Commission (EC) Seventh Framework Programme (FP7). Currently, there is no FDA-approved treatment specifically directed against sepsis mortality. It remains a major life-threatening condition among acute-care patients, accounting for thousands of deaths annually. A better understanding of the basic immune alterations which occur in sepsis is imperative to devise a targeted and successful therapy.

This project aimed to delineate the nature of some of those derangements, specifically to address the mechanisms and prevention of early mortality in experimental sepsis. It focused on effective implementation of the ‘from bench to bedside’ philosophy, and generated data which filled a number of gaps in understanding the pathophysiological process that leads to death in early sepsis. In addition, its targeted pre-clinical data has helped in the design and production of the tools needed to improve the survival of septic patients.

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