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This report describes the preparation, validation and certification of the substance concentration of estradiol-17 beta in 3 lyophylized serum materials of human origin (CRM 576, CRM 577 and CRM 578). The certified reference materials (CRMs) have been shown to be homogenous and stable on storage. The method of analysis used for certification was isotope dilution gas chromatography/mass spectrometry. The CRMs are primarily intended for trueness assessment and internal quality control of reference measurement procedures.

Additional information

Authors: THIENPONT L M R, Faculty of Pharmaceutical Sciences, University of Ghent (BE);DE LEENHEER A P, Faculty of Pharmaceutical Sciences, University of Ghent (BE);DIRSCHERL C, CEC Bruxelles (BE)
Bibliographic Reference: EUR 17540 EN (1997) 47pp., FS, free of charge
Availability: Available from the DG XII Documentation Centre, European Commission, 200 rue de la Loi, B-1049 Bruxelles (BE), Fax: +32-2-2969823
ISBN: ISBN 92-828-0051-2
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