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The present review addresses the role of food constituents in the etiology of metabolic conditions and chronic diseases, mostly related to energy metabolism and substrate regulation, such as obesity and non-insulin-dependent diabetes mellitus. Second, attention is paid to malnutrition, a major cause of mortality and morbidity in developing countries, which may now be a cause for concern in Europe because of the increasing number of elderly people in the population. Finally, the role of diet during exercise, a condition of enormous substrate demands, is evaluated. Based on a critical evaluation of the existing knowledge in the literature, implications for future research in relation to functional foods are discussed.

This is one of six thematic papers produced within the concerted action 'Functional Food Science in Europe' (FUFOSE), which is part of the European Commission's Fourth Framework Programme for research and technological development.

Additional information

Authors: SARIS W H M, Nutrition Research Centre, Maastricht University (NL);BLAAK E, Nutrition Research Centre, Maastricht University (NL);ASP N G L, Chemical Centre, Applied Nutrition and Food Chemistry, University of Lund (SE);BJÖRCK I, Chemical Centre, Applied Nutrition and Food Chemistry, University of Lund (SE);BORNET F, Vilvoorde Research and Development Centre, Nutrition and Health Service, Vilvoorde (BE);BROUNS F, Novartis Nutrition Research Unit, Maastricht (NL);FRAYN K N., Oxford Lipid Metabolism Group, Radcliffe Infirmary, Oxford (GB);FÜRST P, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart (DE);RICCARDI G, Dipartimento di Medicina Clinica e Sperimentale, Universitá degli Studi di Napoli (IT);ROBERFROID M, UCL, École de Pharmacie, Brussels (BE);VOGEL M, Dipl. Biochemiker-Biochemisches Lab, Südzucker AG Mannheim/Ochsenfurt, Pfalz (DE)
Bibliographic Reference: A paper published in 'Functional food science in Europe - volume 1', EUR 18591 EN, pp.S47-S75.
Availability: EUR-OP reference: CG-NO-18591-EN-S; price: 71 euros (set of 3 volumes). Available from EUR-OP sales agents. URL:
ISBN: ISBN: 92-828-4776-4 (3
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