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Biokinetics and Dosimetry of Internal Contamination - BIODOS, Summary

Project ID: FIGD-CT-2000-00053
Funded under: FP5-EAECTP C


Assessments of doses and risks to workers and to the public exposed to radionuclides require biokinetic models which describe the behaviour of the radionuclides from their entry into the body until their final elimination and dosimetric models for calculating doses within tissues. Biokinetic models describing the absorption of radionuclides after ingestion or inhalation and subsequent systemic behaviour, published by the International Commission on Radiological Protection (ICRP), are widely used in dose calculations but are subject to revision as knowledge improves.
The overall objective was to improve the scientific basis of existing biokinetic and dosimetric models and to provide new and improved models. The work comprised two parts focused respectively on the delivery of new systemic, alimentary tract and breast-milk models, and on improvement of the HRTM. It combined established experimental and mathematical modelling expertise, including human, animal and in vitro studies. The work was divided into 9 work packages (WPs). WPs 1 and 5 were designed to provide new data for inclusion in the models whereas the others were aimed at developing the models described above.

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