Community Research and Development Information Service - CORDIS


Radionuclides Biokinetics Database (RBDATA-EULEP), Final report (summary)

Project ID: FIR1-CT-2000-20056
Funded under: FP5-EAECTP C


There is potential for people to be irradiated as a result of internal contamination by a wide range of radionuclides, which can be in a wide variety of chemical forms, both in the workplace and in the environment. For most people, by far the largest source of internal radiation exposure is radon gas, which is produced naturally in rocks and soils, and accumulates in enclosed spaces such as buildings. Nevertheless, there is generally far greater concern about artificially produced radionuclides amongst environmental pressure groups, the public, media, and politicians. For only a few kinds of internal contamination, such as inhalation of radon and certain medical exposures, do epidemiological studies enable a direct assessment to be made of the risks to people?
In all other situations, 'internal dosimetry' provides a systematic basis for assessing the risks from exposure to any radionuclide in any physico-chemical form, based on the radiation doses to organs and tissues. This process, however, requires information on the 'biokinetics' of radionuclides within the body after entry (intake): their distribution between organs, retention in each organ and subsequent excretion. This information is used to develop mathematical 'models' to calculate the distribution of radioactivity and hence the resulting radiation dose to each organ.

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