Community Research and Development Information Service - CORDIS


Genetics of Radiation Carcinogenesis (GENRAD), Final report (summary)

Project ID: FIGH-CT-1999-00001
Funded under: FP5-EAECTP C


Estimations of the risk of an individual developing cancer through exposure to ionizing radiation are based primarily on the long-term follow-up of exposed populations. The extrapolation of dose-effect data derived from these epidemiological studies presents several problems. One growing concern about the validity of extrapolated epidemiological data is the ability of small population samples to accurately predict cancer risk in the global human population. It is now becoming increasingly clear that genetic variation plays a major role in determining the incidence of cancer. On an individual level inheritance of mutated tumour suppressor genes such as p53 or Rb1 greatly increases lifetime risk of developing cancer. On a population level national cancer rates vary dramatically, and whilst environmental and behavioural factors make a contribution, genetic factors also contribute to population risk. Currently very little is known about the genetic component of the risk of radiation carcinogenesis, preventing the inclusion of genetic risk factors in radiation protection models.

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