Community Research and Development Information Service - CORDIS


Induction, Repair and Biological Consequences of DNA Damages Caused By Radiations Of Various Qualities ("RADNA"), Summary

Project ID: FIGH-CT-1999-00012
Funded under: FP5-EAECTP C


The RADNA project focuses on the role of radiation-induced DNA damage, particularly double-strand breaks (DSB), in the production of chromosome aberrations and mutations as critical events in the induction of cancer. Underlying these studies are investigations into the role of DNA repair processes, particularly those involving DSB, in subsequent biological effects. The project utilizes conventional irradiation methods, and innovative microbeam technologies coupled with single-cell assays of response. The objective is to map out responses at the level of individual cells. The overall aim of the project is to provide data that will contribute to mechanistic modelling of radiation risk, particularly in respect of radiation quality factors at low doses.

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