Community Research and Development Information Service - CORDIS


Nanobiotechnology for the coating of medical devices (PectiCoat) - Publishable Executive Summary

Project ID: 517036
Funded under: FP6-NMP


A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with novel and appropriate biological and bioactive properties using defined and tailored polysaccharides. The biomolecules that are to be grafted onto surfaces to function as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans (RG-I), which are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials.
The goal of the programme is the fine-tuning of the surface properties of a range of biomaterials to optimize the interaction between the foreign materials and the host tissues in medical applications. Our cross-disciplinary research will promote a growth of the understanding of the molecular structurefunction relationships of polysaccharide-modified surfaces and devices. With the realization of these goals a breakthrough in biomaterials production will be introduced to the biomedical industry.

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