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CellPROM - Cell Programming by Nanoscaled Devices (CellPROM) - Publishable Executive Summary

Project ID: 500039
Funded under: FP6-NMP


The 6th Framework Programme of the European Union introduced new funding instruments aimed at stimulating the development and implementation of specific key technologies within the European Re-search Area. Integrated Projects belong to these new instruments and group together numerous partners from European research centres to collaborate on a large-scale innovative project. CellPROM - with a total volume of EUR 26 Mio the largest Integrated Project within the thematic priority of NMP, nanobiotechnologies - unites academic and industrial researchers (26 partners) from 12 countries and is coordinated by Prof. Dr. Guenter Fuhr, head of the Fraunhofer Institute for Biomedical Engineering (IBMT) in Germany. The main objective of the project running over four years being non-invasive "reprogramming" of the destiny of individual cells on an industrial scale, the abbreviation "CellPROM" stands for "Cell Programming by nanoscaled devices".
The principle relies on specific reactions of cell surface receptors in response to contact with customised nanostructured surfaces - the NanoScapes - whose macromolecular landscapes mimic biological surfaces triggering processes like immune response and stem cell differentiation in the human body. The project started in March 2004 and will be completed in February 2008.
Since the transmission of the reprogramming or differentiation information from the surface receptor to the nucleus of the cell occurs via natural intracellular signal pathways and without further technical interference, this approach promises a minimisation of undesirable side effects of artificial cell imprinting, while its mastery on an industrial scale opens up important areas of application in the fields of biotechnology, medicine, pharmacy and general technological development.

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