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Sensing Biosystems and their Dynamics in fluids with Organic Transistors (BIODOT) - Publishable Executive Summary

Project ID: 32652
Funded under: FP6-NMP


The detection of biological and chemical species is central to many areas of health care and the life sciences, ranging from uncovering and diagnosing disease, to the discovery and screening of new drug molecules. Neuroscience, especially diagnostics and therapies of neurological diseases, demand for development of new devices with a highly sensitive mechanism of transduction of the biological and chemical signals. Devices based on organic semiconductors emerge as a powerful and versatile class of ultra-sensitive electrical transducers for direct and dynamic detection of biological species. In fact, they can be fabricated and easily integrated with micro- and nanofluidics devices by the use of sustainable nanofabrication techniques, downscaled and endowed with specific recognition functionality by design and tailoring of the materials.
The vision of BIODOT is a hybrid bio-organic technology for transduction of dynamical phenomena of biosystems in-vitro. The device that will be developed is based on organic ultra thin film transistors integrated with microfluidics. It will respond to subtle changes of the electrostatic charge at the interface between the biosystem in the solution and the organic semiconductor. These changes are due, for instance, to the flow of ions, the adsorption and diffusion of charged or polarisable molecules, the motion of large biomolecules, the activity of cells grown on the organic semiconductor. Dynamical phenomena at multiple length scales govern the operations and the functionality of living systems. Signalling across neurons involves transport and diffusion of ions and molecules across membranes and synapses. Low frequency motions control the hierarchical organisation of proteins and membranes, which play a key role in the molecular pathology of many neurological diseases.
The transduction of the dynamical behaviour of a) peptides involved in neurological functions, b) phospholipids and functional membranes, c) neurons and glia cell

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