Community Research and Development Information Service - CORDIS


Nanoscale Functionalities for Targeted Drug Delivery of Biopharmaceutics (NANOBIOPHARMACEUTICS) - Publishable Executive Summary

Project ID: 26723
Funded under: FP6-NMP


The NanoBioPharmaceutics project aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of molecular, nano- and micro-scale functionalities for targeted delivery of therapeutic peptides and proteins (biopharmaceutics). The development of functionalized nanocarriers and nanoparticle-based microcarriers for P/P delivery is both an important scientific challenge and potentially a business breakthrough for the biopharmaceutical industry. NanoBioPharmaceutics is focused on the development of functionalized nanocarriers for the treatment of various diseases based on targeted, controlled delivery of Protein/Peptide (P/P) drugs. More specifically, NanoBioPharmaceutics addresses the following scientific and technological objectives:
- Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based microcarriers for targeted delivery of P/P drugs via oral, pulmonary and Blood Brain Barrier (BBB) crossing administration routes.
- Toxicological screening of the nanocarriers and investigation of the release profile of P/P drugs under various environmental conditions as well as the assessment of the biocompatibility and biodegradability of the new formulations.
- Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung.
- Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties.
- Establishment of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB).

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