Community Research and Development Information Service - CORDIS

Development of resorbable biodegradable polymers for the preparation of coated particles for drug delivery

Drug targeting using polymeric microspheres injected into the circulating blood could have considerable impact in many disease conditions, especially cancer chemotherapy. Biodegradable and bioresorbable polymers suitable for the coating of preformed carrier particles have been synthesised. They include poly(lactide coglycolide), polymalic acid derivatives, poly L-lysine citramide and modified polyamidoamines. Emulsification techniques have been used for the preparation of poly(lactide coglycolide) and albumin microspheres of sizes of 100 nm and 1000 nm and biodegradation studies on related particle samples have commenced. Chemical procedures for the coupling of polyoxyethylene groups onto linear serum albumin have been developed. Diagnostic secondary ion mass spectrometry (SIMS) spectra of coating polymers and particles have been obtained as background to the surface analysis of coated systems.

A chosen polymer will cause particles injected into the blood to remain in the circulation (and thus to avoid deposition at undesired sites such as the resident macrophages in liver) or to be targeted passively to the bone marrow. Coated particles carrying attached homing moieties in the form of sugar residues or monoclonal antibodies will be developed for active targeting opportunities. Particles prepared from polylactide coglycolide demonstrated high loading of polypeptides that were released slowly over a 30 day period.

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