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COATIM Résumé de rapport

Project ID: 278425
Financé au titre de: FP7-HEALTH
Pays: Belgium

Periodic Report Summary 1 - COATIM (Development of antibiofilm coatings for implants)

Project Context and Objectives:

Biofilms, groups of microorganisms that stick together on different surfaces, can be found on medical devices like implants. The most recent generation of implants with open porosity enables fast osseointegration, but also present an increased risk of microbial biofilm-associated infections.

Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, thisFP7-HEALTH COATIM consortium, aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules with inhibitory activity against microbial biofilms.

Project Results:

In COATIM, antibiofilm molecules (ABMs) were identified in previous drug screening programs conducted by five COATIM partners. These molecules were selected for inhibitory activity against bacterial and/or fungal biofilms (either inhibiting their formation or eradicating biofilms including persisters). Out of 100 previously selected compounds, 5 ABMs were selected based on (1) their ability to inhibit biofilm formation of different bacterial and fungal species , (2) toxicity againstnematodes, (3) toxicity profiles for different human primary cell types, which are relevant for implant fixation, (4) remaining activity upon gamma-irradiation, as this technique will be used to sterilize the implants and (5) presence of chemical groups that allow covalent binding to the titanium disks. These 5 compounds are currently coated to titanium implant substrates, which serve as a model for dental and orthopaedic implants. In parallel, a biofilm mouse colonization model was developed and the mode of action of these ABMs is being unraveled.

Potential Impact:

Next, the ABM-coated implants will be evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating will be applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry.

COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe.

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Life Sciences