Community Research and Development Information Service - CORDIS


COCOPOPS — Result In Brief

Project ID: 328985
Funded under: FP7-PEOPLE
Country: Spain

Novel nanoparticles for biological applications

European researchers generated a novel class of sophisticated hybrid nanomaterials that exhibit remarkable cellular compatibility and could be exploited for medical applications.
Novel nanoparticles for biological applications
Metal nanoparticles (NPs) show remarkable potential in fields as diverse as catalysis and medicine due to their distinctive chemical, physical and optical properties. However, they require efficient synthetic protocols to achieve careful control during their self-assembly and obtain the desirable NP shapes, sizes and composition in high yield with minimal cost and toxicity. One emerging approach involves the use of polyoxometalates (POMs) as reducing, capping and stabilising agents, but it remains relatively unexplored.

POMs are polyatomic ions containing several oxygen atoms arranged in a 3D framework with various metals. They present an unmatched range of chemical and physical properties, and can serve as building blocks for the realisation of novel materials.

Scientists on the EU-funded COCOPOPS (The complimentary combination of polyoxometalates and metal nanoparticles) project utilised POMs to prepare colloidal metal NPs, and combine them with NPs to generate hybrid nanomaterials. The resultant materials exhibited responsive and switchable properties at the nano scale and could find application as catalysts and antimicrobial and anticancer materials.

In vitro cell studies indicated the suitability of the composite nanomaterials for biological applications by displaying massive cellular internalisation as well as activity against tumour cells. The COCOPOPS work resulted in a total of four publications in peer-reviewed journals and several presentations in international conferences.

The new synthetic roots generated during COCOPOPS are anticipated to boost the implementation of POMs in the generation of novel hybrid nanomaterials for a number of different applications.

Related information


Nanomaterials, medical applications, metal nanoparticles, polyoxometalates, cancer
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