Community Research and Development Information Service - CORDIS

New ways to make amines

Researchers in the EU have created new green methods to produce amines, a common chemical precursor molecule, that yield only water as a waste product.
New ways to make amines
Amines are important precursors for multiple industrially useful chemicals as well as several common biological molecules. Despite this, current processes to create amines rely on wasteful high-energy processes under harsh conditions.

Backed by EU funding, the AMINATION (Synthesis of amines from alcohols by metal-catalyzed reactions) initiative sought a way to make production of amines a waste-free and environmentally friendly process using the metal-catalysed amination of alcohols.

The appeal of such a process is that it does not require harsh conditions and produces water as a side product. This makes it much more environmentally friendly than current methods. However, the process does rely on specific catalysts that require testing and optimisation.

Researchers began by creating two ruthenium-based catalysts to synthesise indoles, a common amine. They used a different ruthenium catalyst to deconstruct specific cyclic compounds, another important step in this process.

Next, AMINATION studied iron-based catalysts for this reaction, as these catalysts are more environmentally friendly than their ruthenium counterparts. The results clearly showed that iron-based catalysts can be used successfully for this type of reaction.

The research conducted during AMINATION paves the way for new approaches to synthesising amine compounds. This will add value to both research and the industrial synthesis sector.

Related information


Amines, AMINATION, environmentally friendly, ruthenium, iron-based catalysts
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