Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS


NETSIGNAL Berichtzusammenfassung

Project ID: 323113
Gefördert unter: FP7-IDEAS-ERC
Land: United Kingdom

Mid-Term Report Summary - NETSIGNAL (Signal Formation in Synaptic Circuits with Astroglia)

In the past decade, astroglia have emerged as an active and critical partner in neural circuit communication in the brain, in health and disease. However, the increasing variety of mechanisms which reportedly contribute to astroglia-neuron signal exchange is at a conceptual bottleneck. How these multiple and diverse mechanisms relate to the functional organisation of astroglia, whether this relationship persists or whether it adapts to neural activity remains poorly understood. Our overall objective is to establish principles that guide signal formation, integration and propagation in neural circuits interacting with astroglia.

In the reporting period we have established all major cutting-edge techniques designated as per the planned research strategy. These include two-photon excitation imaging, in brain slices and in intact animals, combined with single-cell electrophysiology; time-resolved fluorescence imaging; high-level network models incorporating glial cells; gene targeting and super-resolution methods. Equipped with these approaches, we have so far established a relationship between synaptic identity and glial coverage, found an important feature of the glial transporter of inhibitory neurotransmitter GABA, identified axonal plasticity underlying classical neuronal adaptation, unveiled information-rich landscapes of calcium in neural and astroglial assemblies. The methods established and the results obtained yield some conceptual insights into the basic machinery underpinning the activity of brain circuits with astroglia, also providing a solid basis to achieve scientific of the project a whole.

Reported by

United Kingdom
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