Community Research and Development Information Service - CORDIS

Periodic Report Summary 1 - NEAT BIO-ADHESIVES (A New Molecular Approach for Designing Bio-Adhesive Materials)

Tissue adhesives are attractive alternatives to sutures and staples since they can be applied more quickly, cause less pain, are more economical, and may require less equipment. They may also obviate the need for suture removal, and can release drugs locally in a sustained manner. Designing tissue-adhesive materials are of great importance as an advanced tool for wound healing and covering, bleeding control, drug delivery and other medical applications. The objective of this grant proposal was to define a novel approach to closing wounds using tissue adhesives in the parenchyma of solid, soft organs. The current mainstay of wound closure, inside the body, is suturing and stapling. Tissue adhesives, under the appropriate circumstances, may provide attractive alternatives to sutures and staples, since they can be applied more quickly, cause less pain, more economic, and may require less equipment. Tissue adhesives may obviate the need for suture removal, and can release drugs locally in a sustained manner. Our research has involved the synthesis and characterization of functional bio-glues capable of undergoing structural changes when exposed to soft tissues. We have developed our approach in a modular manner, since different properties would be required for different applications (e.g., tissue adhesive versus tissue sealant or different tissue types). This naturally lead to investigations of molecular-recognition processes within the synthetic material to control the formation of desired properties in terms of adhesiveness and structural integrity.
Since the beginning of the project, significant progress has been made:

1. We were able to set our new lab, recruit students and become familiarized with the current literature and methods. We published an editorial paper summarizing the importance of the field and recent trends.
2. We were able to synthesize new multi armed polymers, including polyethylene glycol and its copolymers and were able to modify them with various end groups. Pre-polymers with the selected end groups were successfully synthesized with very high yields. These polymers were fully characterized for chemical and physical properties. The polymers’ rheological profiles were assessed prior to, during and after crosslinking. Mechanical properties, including characterization of adhesiveness were also studied using porcine skin as model. Pre-polymers were viscous and sticky as planned, so as to allow injectability.
3. We were able to test several administration techniques and decided to use double barrel syringe system that allows accurate administration and the best mixing prior to injection.
4. We were able to characterize the cytotoxicity of several pre-polymers. We compared the performance to our system to that of commercially available formulations, namely butyl-cyanoacrylate (VetbondTM, 3M) and fibrin sealant (EvicelTM) and have noticed that cell reaction to our compounds were better or similar to commercially available glues.

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Life Sciences
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