Community Research and Development Information Service - CORDIS


Neuro-penta Report Summary

Project ID: 631416
Funded under: FP7-PEOPLE
Country: France

Periodic Report Summary 1 - NEURO-PENTA (Structure of the brain serotonine 5-HT3 receptor and other mammalian Cys-loop receptors)

Our team aims to better understand how membrane machines operate at the molecular scale, using structural biology. We mainly work with ion channels, and especially with pentameric neurotransmitter-gated channels. Research projects mix state-of-the-art eukaryotic expression systems, solid biochemistry, biophysical characterization with two structural methods: X-ray crystallography and single particle cryo-EM.

Our research is curiosity-driven, but focuses on membrane proteins that play crucial roles in health and disease. For example, current projects are related to nausea, depression and infertility.

In the framework of the Marie Curie CIG project we develop tools to facilitate structural studies of pentameric neurotransmitter-gated receptors and use them to try and solve structures. During the first two years of the project and of the lab, we have established good basis for protein expression and we have promising results -at the biochemical level- with three receptors.

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Life Sciences
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