Community Research and Development Information Service - CORDIS


PathoPhageHost Report Summary

Project ID: 335400
Funded under: FP7-IDEAS-ERC
Country: Israel

Mid-Term Report Summary - PATHOPHAGEHOST (Studying Pathogen Phage Host Interactions)

Unlike lytic phages, temperate phages maintain long-term association with their bacterial host through lysogeny. In this context mutual beneficial interactions can evolve that support efficient co-reproduction. Temperate phages are essentially large DNA insertions, which disrupt the bacterial chromosome and pose a significant burden on the cell. In this research proposal we investigate a fascinating example of a temperate phage that cooperate with its bacterial host. This example describes a case where the phage is integrated within a critical bacterial gene yet serves as dynamic regulatory switch.

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